Endocrine Abstracts

Introduction: Pseudohypoparathyroidism is a rare disorder characterized by end-organ resistance to parathyroid hormone, caused by molecular defects of the PTH receptor. Resulting chronic hypocalcemia and hyperphosphatemia require lifelong treatment with active vitamin D metabolites and monitoring, representing a challenge especially in difficult living conditions.Case report: A 19-year-old woman presented to our clinic with carpopedal spasms and tetany. ...

Background: Hyponatremia due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a very common electrolyte disorder in older patients leading often to hospital admissions. Symptoms can vary between mild disabilities (e.g. nausea, dizziness, attention deficits, gait disturbance) to severe life-threatening conditions (e.g. seizures, coma). Treatment of SIADH is challenging in particular when fluid restriction is limited or even not effective in restoring n...

Introduction: Hyperinsulinaemic hypoglycemia after gastric bypass surgery is a rare but probably underestimated complication. The mechanisms leading to hypoglycemia are complex and incompletely understood and involve several factors: A part from decreasing insulin resistance, caloric restriction and alteration of nutrient delivery, enhanced secretion of insulin and incretins (GLP1 and GIP), altered physiology of other hormones and dysregulation of counterregulatory effectors s...

Introduction: Leydig cell tumors (LCT) are rare testicular tumors, characterized by mostly benign etiology. Due to their secretory activity androgen- and/or estrogen-excess can occur.Case report: A 42-year old patient with recent history of cerebrovascular incident was admitted to the hematology department for diagnostic work-up of new-onset erythrocytosis (hemoglobin 185 g/l [reference 127–163], hematocrit 0.53 [0.37–0.46]). Myeloproliferati...

Objective: Cinacalcet, a calcimimetic that reduces parathyroid hormone (PTH) secretion and serum calcium (S-Ca) levels by increasing the sensitivity of calcium-sensing receptors has been introduced for the treatment of patients with persistent or recurrent primary hyperparathyroidism (PHPT). Within a prospective, non-interventional cohort study we identified patients with newly diagnosed PHPT who have been started on cinacalcet. Patient characteristics, treatment indications a...

Objective: The Swiss Primary HyperParaThyroidism (PHPT) Cohort Study is an ongoing, prospective, non-interventional project collecting clinical, densitometric, biochemical and outcome data in patients with PHPT. The aims are to describe the profile of these patients particularly neurobehavioral and cognitive symptoms, changes in calcium and PTH over time and treatment modalities.Methods: Patients newly diagnosed with PHPT and with high serum calcium leve...

Introduction: Systemic glucocorticoid therapy may put patients at risk for later adrenal failure during times of stress, but tapering increases cumulative steroid exposure. We prospectively evaluated adrenal function and clinically relevant hypocortisolism after abruptly stopping prednisone treatment in patients with exacerbated COPD.Methods: This is a pre-specified analysis of the REDUCE randomized trial (Journal of American Medical Association...